See this hint for more information on how to do that. You can disable automatic keyboard detection to prevent this. The Keyboard Assistant immediately pops up when you plug it in, and this is very annoying. Your Mac thinks the USB dongle is an entire keyboard accessory.Here's how to get it to work in Tiger (and probably prior OS releases): But as with most things, you can get it working on a Mac. Regular AAA batteries make sure it has good power for the laser and are easily replaceable. Targus recently came out with the AMP01US Wireless Multimedia Presenter, which includes a (relatively) bright laser pointer and trackball mouse in a nice package. I've tried quite a few of the presenters on the market. If you are like me and do a lot of presentations, having a good presentation remote is important.